Dataset Information

Brain microglia activation and peripheral adaptive immunity in Parkinson's disease: a multimodal PET study.

ABSTRACT:

Background

Abnormal activation of immune system is an important pathogenesis of Parkinson's disease, but the relationship between peripheral inflammation, central microglia activation and dopaminergic degeneration remains unclear.

Objectives

To evaluate the brain regional microglia activation and its relationship with clinical severity, dopaminergic presynaptic function, and peripheral inflammatory biomarkers related to adaptive immunity.

Methods

In this case-control study, we recruited 23 healthy participants and 24 participants with early-stage Parkinson's disease. ¹⁸F-PBR06 PET/MR for microglia activation, ¹⁸F-FP-DTBZ for dopaminergic denervation, total account of T cells and subpopulations of T helper (Th1/Th2/Th17) cells, and the levels of serum inflammatory cytokines were assessed. Sanger sequencing was used to exclude the mix-affinity binders of ¹⁸F-PBR06-PET.

Results

Compared to healthy controls, patients with Parkinson's disease had an increased ¹⁸F-PBR06-PET standardized uptake value ratio (SUVR) in the putamen, particularly in the ipsilateral side of the motor onset. ¹⁸F-PBR06-PET SUVR was positively associated with ¹⁸F-FP-DTBZ-PET SUVR in the brainstem and not associated with disease severity measured by Hoehn and Yahr stage, MDS-UPDRS III scores. Patients with Parkinson's disease had elevated frequencies of Th1 cells and serum levels of IL10 and IL17A as compared to healthy controls. No significant association between peripheral inflammation markers and microglia activation in the brain of PD was observed.

Conclusion

Parkinson's disease is associated with early putaminal microglial activation and peripheral phenotypic Th1 bias. Peripheral adaptive immunity might be involved in microglia activation in the process of neurodegeneration in PD indirectly, which may be a potential biomarker for the early detection and the target for immunomodulating therapy.

SUBMITTER: Liu SY

PROVIDER: S-EPMC9422161 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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Publications

Brain microglia activation and peripheral adaptive immunity in Parkinson's disease: a multimodal PET study.

Liu Shu-Ying SY Qiao Hong-Wen HW Song Tian-Bin TB Liu Xiu-Lin XL Yao Yun-Xia YX Zhao Chun-Song CS Barret Olivier O Xu Sheng-Li SL Cai Yan-Ning YN Tamagnan Gilles D GD Sossi Vesna V Lu Jie J Chan Piu P

Journal of neuroinflammation 20220829 1

<h4>Background</h4>Abnormal activation of immune system is an important pathogenesis of Parkinson's disease, but the relationship between peripheral inflammation, central microglia activation and dopaminergic degeneration remains unclear.<h4>Objectives</h4>To evaluate the brain regional microglia activation and its relationship with clinical severity, dopaminergic presynaptic function, and peripheral inflammatory biomarkers related to adaptive immunity.<h4>Methods</h4>In this case-control study, ...[more]

PMID: 36038917

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Dataset Information

Brain microglia activation and peripheral adaptive immunity in Parkinson's disease: a multimodal PET study.

Background

Objectives

Methods

Results

Conclusion

Publications

Brain microglia activation and peripheral adaptive immunity in Parkinson's disease: a multimodal PET study.

Similar Datasets

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