Inflammation and adaptive immunity in Parkinson's disease.
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ABSTRACT:
SUBMITTER: Mosley RL
PROVIDER: S-EPMC3253034 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Publications
Inflammation and adaptive immunity in Parkinson's disease.
Mosley R Lee RL Hutter-Saunders Jessica A JA Stone David K DK Gendelman Howard E HE
Cold Spring Harbor perspectives in medicine 20120101 1
The immune system is designed to protect the host from infection and injury. However, when an adaptive immune response continues unchecked in the brain, the proinflammatory innate microglial response leads to the accumulation of neurotoxins and eventual neurodegeneration. What drives such responses are misfolded and nitrated proteins. Indeed, the antigen in Parkinson's disease (PD) is an aberrant self-protein, although the adaptive immune responses are remarkably similar in a range of diseases. ...[more]
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