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The Association of IL7R rs6897932 with Risk of Multiple Sclerosis in Southern Chinese.

ABSTRACT:

Objective

To investigate the association between IL7R rs6897932 and multiple sclerosis (MS) in southern Chinese people.

Methods

In total, 147 MS patients and 530 healthy controls were recruited according to the revised McDonald criteria. The TaqMan method was used for genotyping.

Results

With genetic models, we can observe that the additive model, the dominant model, and the recessive model of IL7R rs6897932 were significantly associated with MS [additive model: p=0.032; dominant model (adjusted): p<0.001, OR=3.61 (95% CI 2.25-5.83); recessive model (adjusted): p<0.001, OR=6.80 (95% CI 3.49-13.89)].

Conclusion

Our results suggest that IL7R rs6897932 is associated with MS in a southern Chinese population. More and larger MS studies to explore the genetic risk factors of MS are warranted.

SUBMITTER: Zhao Z

PROVIDER: S-EPMC9426677 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

The Association of <i>IL7R</i> rs6897932 with Risk of Multiple Sclerosis in Southern Chinese.

Zhao Zongbo Z Xue Jianzhong J Zhuo Ziliang Z Zhong Wei W Liu Hui H

Neuropsychiatric disease and treatment 20220826

<h4>Objective</h4>To investigate the association between <i>IL7R</i> rs6897932 and multiple sclerosis (MS) in southern Chinese people.<h4>Methods</h4>In total, 147 MS patients and 530 healthy controls were recruited according to the revised McDonald criteria. The TaqMan method was used for genotyping.<h4>Results</h4>With genetic models, we can observe that the additive model, the dominant model, and the recessive model of <i>IL7R</i> rs6897932 were significantly associated with MS [additive mode ...[more]

PMID: 36052273

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