Ontology highlight
ABSTRACT:
SUBMITTER: Pinho MG
PROVIDER: S-EPMC94384 | biostudies-literature | 2000 Feb
REPOSITORIES: biostudies-literature
Pinho M G MG de Lencastre H H Tomasz A A
Journal of bacteriology 20000201 4
The gene pbpC from Staphylococcus aureus was sequenced: it encodes a 691-amino-acid protein with all of the conserved motifs of a class B high-molecular-weight penicillin-binding protein (PBP), including the transpeptidase conserved motifs SXXK, SXN, and KTG. Insertional inactivation of pbpC and introduction of the intact gene in a laboratory mutant missing PBP 3 showed that the pbpC gene encodes the staphylococcal PBP 3. Inactivation of pbpC caused no detectable change in the muropeptide compos ...[more]