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Catalytic Asymmetric Allylic Alkylation with Arylfluoroacetonitriles.

ABSTRACT: A palladium(phosphinoxazoline) catalyzed method for asymmetric allylic alkylation of α-aryl-α-fluoroacetonitriles is introduced. This reaction achieves C-C bond formation and incorporation of two adjacent chirality centers with moderate to good yields, high enantioselectivities, and up to 15:1 dr.

SUBMITTER: Sripada A

PROVIDER: S-EPMC9444989 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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Catalytic Asymmetric Allylic Alkylation with Arylfluoroacetonitriles.

Sripada Archita A Wolf Christian C

The Journal of organic chemistry 20220817 17

A palladium(phosphinoxazoline) catalyzed method for asymmetric allylic alkylation of α-aryl-α-fluoroacetonitriles is introduced. This reaction achieves C-C bond formation and incorporation of two adjacent chirality centers with moderate to good yields, high enantioselectivities, and up to 15:1 <i>dr</i>. ...[more]

PMID: 35975680

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