Dataset Information

Genomic Landscape Alterations in Primary Tumor and Matched Lymph Node Metastasis in Hormone-Naive Prostate Cancer Patients.

ABSTRACT:

Background

Prostate cancer (PCa) is a disease with a wide range of clinical manifestations. Up to the present date, the genetic understanding of patients with favorable or unfavorable prognosis is gaining interest for giving the appropriate tailored treatment. We aimed to investigate genetic changes associated with lymph node metastasis in a cohort of hormone-naïve Pca patients.

Methods

We retrospectively analyzed data from 470 patients who underwent surgery for PCa between 2010 and 2020 at the Department of Urology, University of Catania. Inclusion criteria were patients with lymph node metastasis and patients with PCa with extra capsular extension (pT3) and negative lymph node metastasis. The final cohort consisted of 17 different patients (11 PCa with lymph node metastasis and 6 PCa without lymph node metastasis). Through the cBioPortal online tool, we analyzed gene alterations and their correlations with clinical factors.

Results

A total of 688 intronic, synonym and nonsynonym mutations were sequenced. The gene with the most sequenced mutations was ERBB4 (83 mutations, 12% of 688 total), while the ones with the lower percentage of mutations were AKT1, FGFR2 and MLH1 (1 mutation alone, 0.14%).

Conclusion

In the present study we found mostly concordance concerning the ERBB4 mutation between both primary PCa samples and matched lymph node metastasis, underlining that the identification of alterations in the primary tumor is extremely important for cancer prognosis prediction.

SUBMITTER: Russo GI

PROVIDER: S-EPMC9454441 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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Publications

Genomic Landscape Alterations in Primary Tumor and Matched Lymph Node Metastasis in Hormone-Naïve Prostate Cancer Patients.

Russo Giorgio Ivan GI Bonacci Paolo P Bivona Dalida D Privitera Grete Francesca GF Broggi Giuseppe G Caltabiano Rosario R Vella Jessica J Lo Giudice Arturo A Asmundo Maria Giovanna MG Cimino Sebastiano S Morgia Giuseppe G Stefani Stefania S Musso Nicolò N

Cancers 20220830 17

<h4>Background</h4>Prostate cancer (PCa) is a disease with a wide range of clinical manifestations. Up to the present date, the genetic understanding of patients with favorable or unfavorable prognosis is gaining interest for giving the appropriate tailored treatment. We aimed to investigate genetic changes associated with lymph node metastasis in a cohort of hormone-naïve Pca patients.<h4>Methods</h4>We retrospectively analyzed data from 470 patients who underwent surgery for PCa between 2010 a ...[more]

PMID: 36077746

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