Ontology highlight
ABSTRACT:
SUBMITTER: Henriques A
PROVIDER: S-EPMC9456396 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Henriques Alexandre A Rouvière Laura L Giorla Elodie E Farrugia Clémence C El Waly Bilal B Poindron Philippe P Callizot Noëlle N
International journal of molecular sciences 20220830 17
Mitochondria, α-syn fibrils and the endo-lysosomal system are key players in the pathophysiology of Parkinson's disease. The toxicity of α-syn is amplified by cell-to-cell transmission and aggregation of endogenous species in newly invaded neurons. Toxicity of α-syn PFF was investigated using primary cultures of dopaminergic neurons or on aged mice after infusion in the SNpc and combined with mild inhibition of GBA. In primary dopaminergic neurons, application of α-syn PFF induced a progressive ...[more]