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Intrinsic and extrinsic regulators of Aux/IAA protein degradation dynamics.

ABSTRACT: The plant hormone auxin acts through regulated degradation of Auxin/INDOLE-3-ACETIC ACID (Aux/IAA) proteins to regulate transcriptional events. In this review, we examine the composition and function of each Aux/IAA structural motif. We then focus on recent characterization of Aux/IAA N-terminal disordered regions, formation of secondary structure within these disordered regions, and post-translational modifications (PTMs) that affect Aux/IAA function and stability. We propose how structural variations between Aux/IAA family members may be tuned for differential transcriptional repression and degradation dynamics.

SUBMITTER: Figueiredo MRA

PROVIDER: S-EPMC9464691 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature

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Intrinsic and extrinsic regulators of Aux/IAA protein degradation dynamics.

Figueiredo Marcelo Rodrigues Alves de MRA Strader Lucia C LC

Trends in biochemical sciences 20220708 10

The plant hormone auxin acts through regulated degradation of Auxin/INDOLE-3-ACETIC ACID (Aux/IAA) proteins to regulate transcriptional events. In this review, we examine the composition and function of each Aux/IAA structural motif. We then focus on recent characterization of Aux/IAA N-terminal disordered regions, formation of secondary structure within these disordered regions, and post-translational modifications (PTMs) that affect Aux/IAA function and stability. We propose how structural var ...[more]

PMID: 35817652

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