Ontology highlight
ABSTRACT:
SUBMITTER: Wang N
PROVIDER: S-EPMC9476211 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
ACS omega 20220830 36
The pathogenesis of Alzheimer's disease (AD) is very complex, and there are many hypotheses. Therefore, the development of a multi-target-directed-ligand may be an effective therapeutic strategy. Our previous study showed that notopterol (a natural product from <i>Notopterygium</i>) is a dual BACE1/GSK3β inhibitor. In this study, we designed and synthesized 48 notopterol derivatives with furacoumarin as a scaffold in order to enhance their balanced AChE/BACE1/GSK3β inhibitory activity. Fortunate ...[more]