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Pharmacotherapy for idiopathic pulmonary fibrosis: current landscape and future potential.

ABSTRACT: Over the past two and a half decades, many clinical trials have been designed to determine the safety and efficacy of pharmacotherapy for patients with idiopathic pulmonary fibrosis (IPF). However, so far, only two drugs (pirfenidone and nintedanib) have been found to have an impact on disease progression as defined by reducing the rate of decline in forced vital capacity over a year among IPF patients with mild to moderate impairment in lung function. These two drugs have been approved for treatment of IPF by regulatory agencies and are currently in clinical use worldwide. This article summarises the current landscape of pharmacotherapy for IPF and highlights the prospects and potential of new therapies that are currently being pursued in clinical trials.

SUBMITTER: Raghu G

PROVIDER: S-EPMC9488742 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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Pharmacotherapy for idiopathic pulmonary fibrosis: current landscape and future potential.

Raghu Ganesh G

European respiratory review : an official journal of the European Respiratory Society 20170927 145

Over the past two and a half decades, many clinical trials have been designed to determine the safety and efficacy of pharmacotherapy for patients with idiopathic pulmonary fibrosis (IPF). However, so far, only two drugs (pirfenidone and nintedanib) have been found to have an impact on disease progression as defined by reducing the rate of decline in forced vital capacity over a year among IPF patients with mild to moderate impairment in lung function. These two drugs have been approved for trea ...[more]

PMID: 28954769

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