Dataset Information

The genetic architecture of phenotypic diversity in the Betta fish (Betta splendens).

ABSTRACT: The Betta fish displays a remarkable variety of phenotypes selected during domestication. However, the genetic basis underlying these traits remains largely unexplored. Here, we report a high-quality genome assembly and resequencing of 727 individuals representing diverse morphotypes of the Betta fish. We show that current breeds have a complex domestication history with extensive introgression with wild species. Using a genome-wide association study, we identify the genetic basis of multiple traits, including coloration patterns, the "Dumbo" phenotype with pectoral fin outgrowth, extraordinary enlargement of body size that we map to a major locus on chromosome 8, the sex determination locus that we map to dmrt1, and the long-fin phenotype that maps to the locus containing kcnj15. We also identify a polygenic signal related to aggression, involving multiple neural system-related genes such as esyt2, apbb2, and pank2. Our study provides a resource for developing the Betta fish as a genetic model for morphological and behavioral research in vertebrates.

SUBMITTER: Zhang W

PROVIDER: S-EPMC9491723 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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The genetic architecture of phenotypic diversity in the Betta fish (<i>Betta splendens</i>).

Zhang Wanchang W Wang Hongru H Brandt Débora Y C DYC Hu Beijuan B Sheng Junqing J Wang Mengnan M Luo Haijiang H Li Yahui Y Guo Shujie S Sheng Bin B Zeng Qi Q Peng Kou K Zhao Daxian D Jian Shaoqing S Wu Di D Wang Junhua J Zhao Guang G Ren Jun J Shi Wentian W van Esch Joep H M JHM Klingunga Sirawut S Nielsen Rasmus R Hong Yijiang Y

Science advances 20220921 38

The Betta fish displays a remarkable variety of phenotypes selected during domestication. However, the genetic basis underlying these traits remains largely unexplored. Here, we report a high-quality genome assembly and resequencing of 727 individuals representing diverse morphotypes of the Betta fish. We show that current breeds have a complex domestication history with extensive introgression with wild species. Using a genome-wide association study, we identify the genetic basis of multiple tr ...[more]

PMID: 36129976

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Project description:Developmental plasticity of cardiorespiratory physiology in response to chronic hypoxia is poorly understood in larval fishes, especially larval air-breathing fishes, which eventually in their development can at least partially "escape" hypoxia through air breathing. Whether the development air breathing makes these larval fishes less or more developmentally plastic than strictly water breathing larval fishes remains unknown. Consequently, developmental plasticity of cardiorespiratory physiology was determined in two air-breathing anabantid fishes (Betta splendens and Trichopodus trichopterus). Larvae of both species experienced an hypoxic exposure that mimicked their natural environmental conditions, namely chronic nocturnal hypoxia (12 h at 17 kPa or 14 kPa), with a daily return to diurnal normoxia. Chronic hypoxic exposures were made from hatching through 35 days postfertilization, and opercular and heart rates measured as development progressed. Opercular and heart rates in normoxia were not affected by chronic nocturnal hypoxic. However, routine oxygen consumption M˙O2 (~4 μmol·O2/g per hour in normoxia in larval Betta) was significantly elevated by chronic nocturnal hypoxia at 17 kPa but not by more severe (14 kPa) nocturnal hypoxia. Routine M˙O2 in Trichopodus (6-7 μmol·O2/g per hour), significantly higher than in Betta, was unaffected by either level of chronic hypoxia. PCrit, the PO2 at which M˙O2 decreases as ambient PO2 falls, was measured at 35 dpf, and decreased with increasing chronic hypoxia in Betta, indicating a large, relatively plastic hypoxic tolerance. However, in contrast, PCrit in Trichopodus increased as rearing conditions grew more hypoxic, suggesting that hypoxic acclimation led to lowered hypoxic resistance. Species-specific differences in larval physiological developmental plasticity thus emerge between the relatively closely related Betta and Trichopodus Hypoxic rearing increased hypoxic tolerance in Betta, which inhabits temporary ponds with nocturnal hypoxia. Trichopodus, inhabiting more permanent oxygenated bodies of water, showed few responses to hypoxia, reflecting a lower degree of developmental phenotypic plasticity.

Dataset Information

The genetic architecture of phenotypic diversity in the Betta fish (Betta splendens).

Publications

The genetic architecture of phenotypic diversity in the Betta fish (<i>Betta splendens</i>).

Similar Datasets

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