Dataset Information
Reduced phonemic fluency in progressive supranuclear palsy is due to dysfunction of dominant BA6.
Ontology highlight
ABSTRACT: Background
Reduced phonemic fluency is extremely frequent in progressive supranuclear palsy (PSP), but its neural correlate is yet to be defined.Objective
We explored the hypothesis that poor fluency in PSP might be due to neurodegeneration within a dominant frontal circuit known to be involved in speech fluency, including the opercular area, the superior frontal cortex (BA6), and the frontal aslant tract connecting these two regions.Methods
We correlated performance on a letter fluency task (F, A, and S, 60 s for each letter) with brain metabolism as measured with Fluoro-deoxy-glucose Positron Emission Tomography, using Statistical Parametric Mapping, in 31 patients with PSP.Results
Reduced letter fluency was associated with significant hypometabolism at the level of left BA6.Conclusion
Our finding is the first evidence that in PSP, as in other neurogical disorders, poor self-initiated, effortful verbal retrieval appears to be linked to dysfunction of the dominant opercular-aslant-BA6 circuit.
SUBMITTER: Isella V
PROVIDER: S-EPMC9492952 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Publications
Reduced phonemic fluency in progressive supranuclear palsy is due to dysfunction of dominant BA6.
Frontiers in aging neuroscience 20220908
<h4>Background</h4>Reduced phonemic fluency is extremely frequent in progressive supranuclear palsy (PSP), but its neural correlate is yet to be defined.<h4>Objective</h4>We explored the hypothesis that poor fluency in PSP might be due to neurodegeneration within a dominant frontal circuit known to be involved in speech fluency, including the opercular area, the superior frontal cortex (BA6), and the frontal aslant tract connecting these two regions.<h4>Methods</h4>We correlated performance on a ...[more]
