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Minimal residual disease in EGFR-mutant non-small-cell lung cancer.

ABSTRACT: Targeted therapy with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) is an effective treatment for EGFR-mutant non-small-cell lung cancer (NSCLC), however most patients invariably relapse after a period of minimal residual disease (MRD). This mini-review explores the mechanistic pathways leading to tumour dormancy, cellular senescence and epigenetic changes involving YAP/TEAD activation. We describe the various approaches of utilising TKIs in combination with agents to intensify initial depth of response, enhance apoptosis and target senescence-like dormancy. This mini-review will also highlight the potential novel therapies under development targeting MRD to improve outcomes for patients with EGFR-mutant NSCLC.

SUBMITTER: Bain NT

PROVIDER: S-EPMC9533094 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Minimal residual disease in <i>EGFR</i>-mutant non-small-cell lung cancer.

Bain Nathan T NT Wang Yang Y Arulananda Surein S

Frontiers in oncology 20220921

Targeted therapy with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) is an effective treatment for <i>EGFR-</i>mutant non-small-cell lung cancer (NSCLC), however most patients invariably relapse after a period of minimal residual disease (MRD). This mini-review explores the mechanistic pathways leading to tumour dormancy, cellular senescence and epigenetic changes involving YAP/TEAD activation. We describe the various approaches of utilising TKIs in combination with ag ...[more]

PMID: 36212398

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