Dataset Information

The association of patient age with postoperative morbidity and mortality following resection of intracranial tumors.

ABSTRACT:

Introduction

The postoperative functional status of patients with intracranial tumors is influenced by patient-specific factors, including age.

Research question

This study aimed to elucidate the association between age and postoperative morbidity or mortality following the resection of brain tumors.

Material and methods

A multicenter database was retrospectively reviewed. Functional status was assessed before and 3-6 months after tumor resection by the Karnofsky Performance Scale (KPS). Uni- and multivariable linear regression were used to estimate the association of age with postoperative change in KPS. Logistic regression models for a ≥10-point decline in KPS or mortality were built for patients ≥75 years.

Results

The total sample of 4864 patients had a mean age of 56.4 ± 14.4 years. The mean change in pre-to postoperative KPS was -1.43. For each 1-year increase in patient age, the adjusted change in postoperative KPS was -0.11 (95% CI -0.14 - - 0.07). In multivariable analysis, patients ≥75 years had an odds ratio of 1.51 to experience postoperative functional decline (95%CI 1.21-1.88) and an odds ratio of 2.04 to die (95%CI 1.33-3.13), compared to younger patients.

Discussion

Patients with intracranial tumors treated surgically showed a minor decline in their postoperative functional status. Age was associated with this decline in function, but only to a small extent.

Conclusion

Patients ≥75 years were more likely to experience a clinically meaningful decline in function and about two times as likely to die within the first 6 months after surgery, compared to younger patients.

SUBMITTER: Yang Y

PROVIDER: S-EPMC9560674 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Publications

The association of patient age with postoperative morbidity and mortality following resection of intracranial tumors.

Yang Yang Y Zeitlberger Anna M AM Neidert Marian C MC Staartjes Victor E VE Broggi Morgan M Zattra Costanza Maria CM Vasella Flavio F Velz Julia J Bartek Jiri J Fletcher-Sandersjöö Alexander A Förander Petter P Kalasauskas Darius D Renovanz Mirjam M Ringel Florian F Brawanski Konstantin R KR Kerschbaumer Johannes J Freyschlag Christian F CF Jakola Asgeir S AS Sjåvik Kristin K Solheim Ole O Schatlo Bawarjan B Sachkova Alexandra A Bock Hans Christoph HC Hussein Abdelhalim A Rohde Veit V Broekman Marike L D MLD Nogarede Claudine O CO Lemmens Cynthia M C CMC Kernbach Julius M JM Neuloh Georg G Krayenbühl Niklaus N Ferroli Paolo P Regli Luca L Bozinov Oliver O Stienen Martin N MN

Brain & spine 20211021

<h4>Introduction</h4>The postoperative functional status of patients with intracranial tumors is influenced by patient-specific factors, including age.<h4>Research question</h4>This study aimed to elucidate the association between age and postoperative morbidity or mortality following the resection of brain tumors.<h4>Material and methods</h4>A multicenter database was retrospectively reviewed. Functional status was assessed before and 3-6 months after tumor resection by the Karnofsky Performanc ...[more]

PMID: 36247402

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Dataset Information

The association of patient age with postoperative morbidity and mortality following resection of intracranial tumors.

Introduction

Research question

Material and methods

Results

Discussion

Conclusion

Publications

The association of patient age with postoperative morbidity and mortality following resection of intracranial tumors.

Similar Datasets

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