Ontology highlight
ABSTRACT:
SUBMITTER: Oronsky B
PROVIDER: S-EPMC9562194 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Oronsky Bryan B Gastman Brian B Conley Anthony P AP Reid Christopher C Caroen Scott S Reid Tony T
Cancers 20220927 19
Oncolytic viruses, colloquially referred to as "living drugs", amplify themselves and the therapeutic transgenes that they carry to stimulate an immune response both locally and systemically. Remarkable exceptions aside, such as the recent 14-patient trial with the PD-1 inhibitor, dostarlimab, in mismatch repair (MMR) deficient rectal cancer, where the complete response rate was 100%, checkpoint inhibitors are not cure-alls, which suggests the need for a combination partner like oncolytic viruse ...[more]