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MiRNA: A Promising Therapeutic Target in Cancer.

ABSTRACT: microRNAs are small non-coding RNAs that regulate several genes post-transcriptionally by complementarity pairing. Since discovery, they have been reported to be involved in a variety of biological functions and pathologies including cancer. In cancer, they can act as a tumor suppressor or oncomiR depending on the cell type. Studies have shown that miRNA-based therapy, either by inhibiting an oncomiR or by inducing a tumor suppressor, is effective in cancer treatment. This review focusses on the role of miRNA in cancer, therapeutic approaches with miRNAs and how they can be effectively delivered into a system. We have also summarized the patents and clinical trials in progress for miRNA therapy.

SUBMITTER: Menon A

PROVIDER: S-EPMC9569513 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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miRNA: A Promising Therapeutic Target in Cancer.

Menon Amrutha A Abd-Aziz Noraini N Khalid Kanwal K Poh Chit Laa CL Naidu Rakesh R

International journal of molecular sciences 20220929 19

microRNAs are small non-coding RNAs that regulate several genes post-transcriptionally by complementarity pairing. Since discovery, they have been reported to be involved in a variety of biological functions and pathologies including cancer. In cancer, they can act as a tumor suppressor or oncomiR depending on the cell type. Studies have shown that miRNA-based therapy, either by inhibiting an oncomiR or by inducing a tumor suppressor, is effective in cancer treatment. This review focusses on the ...[more]

PMID: 36232799

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