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Proteasome, a Promising Therapeutic Target for Multiple Diseases Beyond Cancer.

ABSTRACT: Proteasome is vital for intracellular protein homeostasis as it eliminates misfolded and damaged protein. Inhibition of proteasome has been validated as a powerful strategy for anti-cancer therapy, and several drugs have been approved for treatment of multiple myeloma. Recent studies indicate that proteasome has potent therapeutic effects on a variety of diseases besides cancer, including parasite infectious diseases, bacterial/fungal infections diseases, neurodegenerative diseases and autoimmune diseases. In this review, recent developments of proteasome inhibitors for various diseases and related structure activity relationships are going to be summarized.

SUBMITTER: Cao Y

PROVIDER: S-EPMC7585272 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Proteasome, a Promising Therapeutic Target for Multiple Diseases Beyond Cancer.

Cao Yu Y Zhu Huajian H He Ruoyu R Kong Limin L Shao Jiaan J Zhuang Rangxiao R Xi Jianjun J Zhang Jiankang J

Drug design, development and therapy 20201019

Proteasome is vital for intracellular protein homeostasis as it eliminates misfolded and damaged protein. Inhibition of proteasome has been validated as a powerful strategy for anti-cancer therapy, and several drugs have been approved for treatment of multiple myeloma. Recent studies indicate that proteasome has potent therapeutic effects on a variety of diseases besides cancer, including parasite infectious diseases, bacterial/fungal infections diseases, neurodegenerative diseases and autoimmun ...[more]

PMID: 33116419

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