Dataset Information

Laminar-specific functional connectivity mapping with multi-slice line-scanning fMRI.

ABSTRACT: Despite extensive studies detecting laminar functional magnetic resonance imaging (fMRI) signals to illustrate the canonical microcircuit, the spatiotemporal characteristics of laminar-specific information flow across cortical regions remain to be fully investigated in both evoked and resting conditions at different brain states. Here, we developed a multislice line-scanning fMRI (MS-LS) method to detect laminar fMRI signals in adjacent cortical regions with high spatial (50 μm) and temporal resolution (100 ms) in anesthetized rats. Across different trials, we detected either laminar-specific positive or negative blood-oxygen-level-dependent (BOLD) responses in the surrounding cortical region adjacent to the most activated cortex under the evoked condition. Specifically, in contrast to typical Layer (L) 4 correlation across different regions due to the thalamocortical projections for trials with positive BOLD, a strong correlation pattern specific in L2/3 was detected for trials with negative BOLD in adjacent regions, which indicated brain state-dependent laminar-fMRI responses based on corticocortical interaction. Also, in resting-state (rs-) fMRI study, robust lag time differences in L2/3, 4, and 5 across multiple cortices represented the low-frequency rs-fMRI signal propagation from caudal to rostral slices. In summary, our study provided a unique laminar fMRI mapping scheme to better characterize trial-specific intra- and inter-laminar functional connectivity in evoked and resting-state MS-LS.

SUBMITTER: Choi S

PROVIDER: S-EPMC9574235 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature

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Laminar-specific functional connectivity mapping with multi-slice line-scanning fMRI.

Choi Sangcheon S Zeng Hang H Chen Yi Y Sobczak Filip F Qian Chunqi C Yu Xin X Yu Xin X

Cerebral cortex (New York, N.Y. : 1991) 20221001 20

Despite extensive studies detecting laminar functional magnetic resonance imaging (fMRI) signals to illustrate the canonical microcircuit, the spatiotemporal characteristics of laminar-specific information flow across cortical regions remain to be fully investigated in both evoked and resting conditions at different brain states. Here, we developed a multislice line-scanning fMRI (MS-LS) method to detect laminar fMRI signals in adjacent cortical regions with high spatial (50 μm) and temporal res ...[more]

PMID: 35107125

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Dataset Information

Laminar-specific functional connectivity mapping with multi-slice line-scanning fMRI.

Publications

Laminar-specific functional connectivity mapping with multi-slice line-scanning fMRI.

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