Ontology highlight
ABSTRACT:
SUBMITTER: Bonaterra GA
PROVIDER: S-EPMC9578283 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Bonaterra Gabriel A GA Schleper Alexander A Skowronek Maximilian M Kilian Lucia S LS Rink Theresa T Schwarzbach Hans H Heers Hendrik H Hänze Jörg J Rexin Peter P Ramaswamy Annette A Denkert Carsten C Wilhelm Beate B Hegele Axel A Hofmann Rainer R Weihe Eberhard E Kinscherf Ralf R
Cancers 20220922 19
Although growth differentiation factor-15 (GDF-15) is highly expressed in PCa, its role in the development and progression of PCa is unclear. The present study aims to determine the density of GDF-15+ cells and immune cells (M1-/M2 macrophages [MΦ], lymphocytes) in PCa of different Gleason scores (GS) compared to BPH. Immunohistochemistry and double immunofluorescence were performed on paraffin-embedded human PCa and BPH biopsies with antibodies directed against GDF-15, CD68 (M1 MΦ), CD163 (M2 M ...[more]