Proteomics

Dataset Information

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Serum proteomics in prostate cancer patients vs. healthy and benign prostate hyperplasia


ABSTRACT: The study aim was to identify novel serum markers of prostate cancer diagnosis compared to benign prostate hyperplasia and healthy controls

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood

SUBMITTER: Antigoni Manousopoulou  

LAB HEAD: Spiro Garbis

PROVIDER: PXD004575 | Pride | 2016-10-04

REPOSITORIES: Pride

Dataset's files

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Publications

Detection of candidate biomarkers of prostate cancer progression in serum: a depletion-free 3D LC/MS quantitative proteomics pilot study.

Larkin S E T SE   Johnston H E HE   Jackson T R TR   Jamieson D G DG   Roumeliotis T I TI   Mockridge C I CI   Michael A A   Manousopoulou A A   Papachristou E K EK   Brown M D MD   Clarke N W NW   Pandha H H   Aukim-Hastie C L CL   Cragg M S MS   Garbis S D SD   Townsend P A PA  

British journal of cancer 20160929 9


<h4>Background</h4>Prostate cancer (PCa) is the most common male cancer in the United Kingdom and we aimed to identify clinically relevant biomarkers corresponding to stage progression of the disease.<h4>Methods</h4>We used enhanced proteomic profiling of PCa progression using iTRAQ 3D LC mass spectrometry on high-quality serum samples to identify biomarkers of PCa.<h4>Results</h4>We identified >1000 proteins. Following specific inclusion/exclusion criteria we targeted seven proteins of which tw  ...[more]

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