Project description:The Omicron variants spread rapidly worldwide after being initially detected in South Africa in November 2021. It showed increased transmissibility and immune evasion with far more amino acid mutations in the spike (S) protein than the previously circulating variants of concern (VOCs). Notably, on 15 July 2022, we monitored the first VOC / Omicron subvariant BA.2.75 in China from an imported case. Moreover, nowadays, this subvariant still is predominant in India. It has nine additional mutations in the S protein compared to BA.2, three of which (W152R, G446S, and R493Q reversion) might contribute to higher transmissibility and immune escape. This subvariant could cause wider spread and pose a threat to the global situation. Our timely reporting and continuous genomic analysis are essential to fully elucidate the characteristics of the subvariant BA.2.75 in the future.

| S-EPMC9613801 | biostudies-literature

The First Outbreak of Omicron Subvariant BA.5.2 - Beijing Municipality, China, July 4, 2022.

Project description: Not available

| S-EPMC9433762 | biostudies-literature

Emergence of a SARS-CoV-2 Omicron Subvariant BA.2.2 with a 454-Nucleotide Genomic Deletion - Sichuan Province, China, May 10, 2022.

Project description: Not available

| S-EPMC9579981 | biostudies-literature

An Imported Case of BA.2 Lineage of Omicron Variant COVID-19 - Guangdong Province, China, December 28, 2021.

Project description: Not available

| S-EPMC8837461 | biostudies-literature

Neutralization Escape by SARS-CoV-2 Omicron Subvariant BA.4.6.

Project description: Not available

| S-EPMC9634860 | biostudies-literature

Antigenic characterization of SARS-CoV-2 Omicron subvariant BA.4.6.

Project description: Not available

| S-EPMC9705283 | biostudies-literature

Neutralization escape by SARS-CoV-2 Omicron subvariant BA.2.86.

Project description:The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variant BA.2.86 has over 30 mutations in spike compared with BA.2 and XBB.1.5, which raised the possibility that BA.2.86 might evade neutralizing antibodies (NAbs) induced by vaccination or infection. In this study, we show that NAb titers are substantially lower to BA.2.86 compared with BA.2 but are similar or slightly higher than to other current circulating variants, including XBB.1.5, EG.5.1, and FL.1.5.1. Moreover, NAb titers against all these variants were higher in vaccinated individuals with a history of XBB.1.5 infection compared with vaccinated individuals with no history of XBB.1.5 infection, suggesting the potential utility of the monovalent XBB.1.5 mRNA boosters.

| S-EPMC10842519 | biostudies-literature

The Omicron BA.2.2.1 subvariant drove the wave of SARS-CoV-2 outbreak in Shanghai during spring 2022.

Project description: Not available

| S-EPMC9514698 | biostudies-literature

An Imported Case and an Infected Close Contact of the Omicron Variant of SARS-CoV-2 - Guangdong Province, China, December 13, 2021.

Project description: Not available

| S-EPMC8837459 | biostudies-literature