Dataset Information

The First Outbreak of Omicron Subvariant BA.5.2 - Beijing Municipality, China, July 4, 2022.

ABSTRACT:

SUBMITTER: Feng Z

PROVIDER: S-EPMC9433762 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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The First Outbreak of Omicron Subvariant BA.5.2 - Beijing Municipality, China, July 4, 2022.

Feng Zhaomin Z Shen Ying Y Li Shuang S Li Jia J Wang Shaohua S Zhang Zhenquan Z Shen Yunkui Y Li Fu F Pan Yang Y Wang Quanyi Q Huo Da D

China CDC weekly 20220701 30

PMID: 36062071

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Project description:BackgroundThe coronavirus disease 2019 outbreak has hit Beijing since mid-Nov, 2022, with soaring growth of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among children. Therefore, it is vital to determine the clinical manifestations of epidemic SARS-CoV-2 strains in paediatric patients.MethodsIn this study, nucleic acid tests (NATs) for SARS-CoV-2 were performed in paediatric outpatients with symptoms of acute respiratory tract infection during 18 Nov-6 Dec, 2022. Half of the outpatients positive for SARS-CoV-2 were randomly selected to screen for other respiratory pathogens, whereas those with low cycle threshold values in SARS-CoV-2 NATs were amplified and sequenced to determine the SARS-CoV-2 variants. Finally, children positive for SARS-CoV-2 with clinical information in detail were enrolled in a follow-up study to identify potential factors significantly associated with long recovery.ResultsAmong 9625 paediatric outpatients tested for nucleic acid of SARS-CoV-2, 733 (7.62%, 733/9625) were identified as SARS-CoV-2 NAT positive, with only three (0.82%, 3/366) co-infected with other pathogens among 366 randomly selected patients, and 71 (62.83%) determined as Omicron subvariant BF.7 and 42 (37.22%) as BA.5.2 among 113 successfully sequenced. Among the 681 patients with complete clinical information, fever was the most common symptom (96.8%). In a follow-up study of 592 patients, 46.96% became asymptomatic on the third day and 65.71% on the fifth day. Only 1.7% of infected children experienced febrile seizures. Combined with abnormal C-reactive protein, a higher percentage of antibiotics administration was observed. More co-living members and longer duration of first symptoms served as independent risk factors for long-term recovery, especially in children vaccinated for SARS-CoV-2.ConclusionsBF.7 and BA.5.2 were the dominate Omicron subvariants and caused milder infections during the SARS-CoV-2 outbreak in Beijing. The number of co-living members and duration of first symptoms were independent risk factors for long-term recovery.

Dataset Information

The First Outbreak of Omicron Subvariant BA.5.2 - Beijing Municipality, China, July 4, 2022.

Publications

The First Outbreak of Omicron Subvariant BA.5.2 - Beijing Municipality, China, July 4, 2022.

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