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CGAS-STING pathway targeted therapies and their applications in the treatment of high-grade glioma.

ABSTRACT: Median survival of patients with glioblastoma (GBM) treated with standard of care which consists of maximal safe resection of the contrast-enhancing portion of the tumor followed by radiation therapy with concomitant adjuvant temozolomide (TMZ) remains 15 months. The tumor microenvironment (TME) is known to contain immune suppressive myeloid cells with minimal effector T cell infiltration. Stimulator of interferon genes (STING) is an important activator of immune response and results in production of Type 1 interferon and antigen presentation by myeloid cells. This review will discuss important developments in STING agonists, potential biomarkers for STING response, and new combinatorial therapeutic approaches in gliomas.

SUBMITTER: Tripathi S

PROVIDER: S-EPMC9597127 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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cGAS-STING pathway targeted therapies and their applications in the treatment of high-grade glioma.

Tripathi Shashwat S Najem Hinda H Mahajan Akanksha Sanjay AS Zhang Peng P Low Justin T JT Stegh Alexander H AH Curran Michael A MA Ashley David M DM James Charles David CD Heimberger Amy B AB

F1000Research 20220907

Median survival of patients with glioblastoma (GBM) treated with standard of care which consists of maximal safe resection of the contrast-enhancing portion of the tumor followed by radiation therapy with concomitant adjuvant temozolomide (TMZ) remains 15 months. The tumor microenvironment (TME) is known to contain immune suppressive myeloid cells with minimal effector T cell infiltration. Stimulator of interferon genes (STING) is an important activator of immune response and results in producti ...[more]

PMID: 36324813

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