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Prostaglandin production selectively in brain endothelial cells is both necessary and sufficient for eliciting fever.

ABSTRACT: Fever is known to be elicited by prostaglandin E₂ acting on the brain, but its origin has remained disputed. We show in mice that selective deletion of prostaglandin synthesis in brain endothelial cells, but not in neural cells or myeloid cells, abolished fever induced by intravenous administration of lipopolysaccharide and that selective rescue of prostaglandin synthesis in brain endothelial cells reinstated fever. These data demonstrate that prostaglandin production in brain endothelial cells is both necessary and sufficient for eliciting fever.

SUBMITTER: Shionoya K

PROVIDER: S-EPMC9618080 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature

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Prostaglandin production selectively in brain endothelial cells is both necessary and sufficient for eliciting fever.

Shionoya Kiseko K Eskilsson Anna A Blomqvist Anders A

Proceedings of the National Academy of Sciences of the United States of America 20221017 43

Fever is known to be elicited by prostaglandin E<sub>2</sub> acting on the brain, but its origin has remained disputed. We show in mice that selective deletion of prostaglandin synthesis in brain endothelial cells, but not in neural cells or myeloid cells, abolished fever induced by intravenous administration of lipopolysaccharide and that selective rescue of prostaglandin synthesis in brain endothelial cells reinstated fever. These data demonstrate that prostaglandin production in brain endothe ...[more]

PMID: 36252026

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