Ontology highlight
ABSTRACT:
SUBMITTER: Nockemann D
PROVIDER: S-EPMC3944465 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Nockemann Dinah D Rouault Morgane M Labuz Dominika D Hublitz Philip P McKnelly Kate K Reis Fernanda C FC Stein Christoph C Heppenstall Paul A PA
EMBO molecular medicine 20130701 8
The use of opioid agonists acting outside the central nervous system (CNS) is a promising therapeutic strategy for pain control that avoids deleterious central side effects such as apnea and addiction. In human clinical trials and rat models of inflammatory pain, peripherally restricted opioids have repeatedly shown powerful analgesic effects; in some mouse models however, their actions remain unclear. Here, we investigated opioid receptor coupling to K(+) channels as a mechanism to explain such ...[more]