Ontology highlight
ABSTRACT:
SUBMITTER: Boscolo E
PROVIDER: S-EPMC9631803 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Boscolo Elisa E Pastura Patricia P Schrenk Sandra S Goines Jillian J Kang Rachael R Pillis Devin D Malik Punam P Le Cras Timothy D TD
Angiogenesis 20220407 3
Somatic mutations in NRAS drive the pathogenesis of melanoma and other cancers but their role in vascular anomalies and specifically human endothelial cells is unclear. The goals of this study were to determine whether the somatic-activating NRAS<sup>Q61R</sup> mutation in human endothelial cells induces abnormal angiogenesis and to develop in vitro and in vivo models to identify disease-causing pathways and test inhibitors. Here, we used mutant NRAS<sup>Q61R</sup> and wild-type NRAS (NRAS<sup>W ...[more]