Dataset Information

B-cell malignancies and COVID-19: a narrative review.

ABSTRACT:

Background

COVID-19 has been extensively characterized in immunocompetent hosts and to a lesser extent in immunocompromised populations. Among the latter, patients treated for B-cell malignancies have immunosuppression generated by B-cell lymphodepletion/aplasia resulting in a higher susceptibility to respiratory virus infections and poor response to vaccination. The consequence is that these patients are likely to develop severe or critical COVID-19.

Objectives

To examine the overall impact of COVID-19 in patients treated for a B-cell malignancy or receiving chimeric antigen receptor T (CAR-T) immunotherapy administered in case of relapsed or refractory disease.

Sources

We searched in the Medline database to identify relevant studies, trials, reviews, or meta-analyses focusing on SARS-CoV-2 vaccination or COVID-19 management in patients treated for a B-cell malignancy or recipients of CAR-T cell therapy up to July 8^th, 2022.

Content

The epidemiology and the outcomes of COVID-19 in B-cell malignancy patients and CAR-T cell recipients are summarized. Vaccine efficacy in these subgroups is compiled. Considering the successive surges of variants of concern, we propose a critical appraisal of treatment strategies by discussing the use of neutralizing monoclonal antibodies, convalescent plasma therapy, direct-acting antiviral drugs, corticosteroids and immunomodulators.

Implications

For B-cell malignancy patients, preventive vaccination against SARS-CoV-2 remain essential and management of COVID-19 includes the control of viral replication due to protracted SARS-CoV-2 shedding. Passive immunotherapy (monoclonal neutralizing antibody therapy, convalescent plasma therapy) and direct-active antivirals such as remdesivir and nirmatrelvir/ritonavir are the best currently available treatments. Real-world data and sub-group analyses in larger trials are warranted to assess COVID-19 therapeutics in B-cell depleted populations.

SUBMITTER: Luque-Paz D

PROVIDER: S-EPMC9633106 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Publications

B-cell malignancies and COVID-19: a narrative review.

Luque-Paz David D Sesques Pierre P Wallet Florent F Bachy Emmanuel E Ader Florence F

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20221104 3

<h4>Background</h4>COVID-19 has been extensively characterized in immunocompetent hosts and to a lesser extent in immunocompromised populations. Among the latter, patients treated for B-cell malignancies have immunosuppression generated by B-cell lymphodepletion/aplasia resulting in an increased susceptibility to respiratory virus infections and poor response to vaccination. The consequence is that these patients are likely to develop severe or critical COVID-19.<h4>Objectives</h4>To examine the ...[more]

PMID: 36336236

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Dataset Information

B-cell malignancies and COVID-19: a narrative review.

Background

Objectives

Sources

Content

Implications

Publications

B-cell malignancies and COVID-19: a narrative review.

Similar Datasets

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