Ontology highlight
ABSTRACT:
SUBMITTER: Onuma K
PROVIDER: S-EPMC9633284 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Onuma Kunishige K Inoue Masahiro M
Cancer science 20220914 11
Apico-basal polarity is a fundamental property of the epithelium that functions as a barrier, holds cells together, and determines the directions of absorption and secretion. Apico-basal polarity is regulated by extracellular matrix-integrin binding and downstream signaling pathways, including focal adhesion kinase, rouse-sarcoma oncogene (SRC), and RHO/RHO-associated kinase (ROCK). Loss of epithelial cell polarity plays a critical role in the progression of cancer cells. However, in differentia ...[more]