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Quinazolinone-based hybrids with diverse biological activities: A mini-review.

ABSTRACT: Quinazolinone and quinazoline have been shown different pharmacological activities, namely anticancer, anti-inflammatory, anti-hyperlipidemia, analgesic, antihypertensive, and antibacterial. On the other hand, molecular hybridization is a structural modification technique in the design of new ligands which consist of two or more pharmacologically active molecules in one structure. Therefore, due to the importance of the biological activities of quinazolinones for the development of new therapeutic agents, this review emphasizes current findings on various quinazolinone-based hybrids in medicinal chemistry. Moreover, it highlights the biological activities and structure-activity relationship of these hybrids.

SUBMITTER: Rezaeinasab R

PROVIDER: S-EPMC9639715 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Quinazolinone-based hybrids with diverse biological activities: A mini-review.

Rezaeinasab Rezvan R Jafari Elham E Khodarahmi Ghadamali G

Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences 20220927

Quinazolinone and quinazoline have been shown different pharmacological activities, namely anticancer, anti-inflammatory, anti-hyperlipidemia, analgesic, antihypertensive, and antibacterial. On the other hand, molecular hybridization is a structural modification technique in the design of new ligands which consist of two or more pharmacologically active molecules in one structure. Therefore, due to the importance of the biological activities of quinazolinones for the development of new therapeut ...[more]

PMID: 36353342

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