Ontology highlight
ABSTRACT:
SUBMITTER: Gumina DL
PROVIDER: S-EPMC9641665 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Gumina Diane L DL Ji Shuhan S Flockton Amanda A McPeak Kathryn K Stich Dominik D Moldovan Radu R Su Emily J EJ
Development (Cambridge, England) 20221004 19
Placentas from pregnancies complicated by severe early-onset fetal growth restriction (FGR) exhibit diminished vascular development mediated by impaired angiogenesis, but underlying mechanisms remain unknown. In this study, we show that FGR endothelial cells demonstrate inherently reduced migratory capacity despite the presence of fibronectin, a matrix protein abundant in placental stroma that displays abnormal organization in FGR placentas. Thus, we hypothesized that aberrant endothelial-fibron ...[more]