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Genome Sequence of an Early Imported Case of SARS-CoV-2 Delta Variant (B.1.617.2 AY.122) in Iraq in April 2021.

ABSTRACT: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant was first reported in India. Thereafter, the Delta variant became the most prevalent variant globally. Here, we report the complete genome sequence of an early imported case of a SARS-CoV-2 B.1.617.2 AY.122 strain in Iraq. The strain was obtained from a flight passenger from India to Iraq on 20 April 2021.

SUBMITTER: Al-Rashedi NAM

PROVIDER: S-EPMC9671009 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Genome Sequence of an Early Imported Case of SARS-CoV-2 Delta Variant (B.1.617.2 AY.122) in Iraq in April 2021.

Al-Rashedi Nihad A M NAM Alburkat Hussein H Munahi Murad G MG Jasim Ali H AH Salman Batool Kadham BK Oda Basel Saber BS Mossa Abbas Abd-Alsahib AA Abbas Ahmed Abdulrazzaq AA Vapalahti Olli O Sironen Tarja T Smura Teemu T

Microbiology resource announcements 20221017 11

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant was first reported in India. Thereafter, the Delta variant became the most prevalent variant globally. Here, we report the complete genome sequence of an early imported case of a SARS-CoV-2 B.1.617.2 AY.122 strain in Iraq. The strain was obtained from a flight passenger from India to Iraq on 20 April 2021. ...[more]

PMID: 36250864

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Project description:BackgroundThe B.1.617.2 (delta) variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (Covid-19), has contributed to a surge in cases in India and has now been detected across the globe, including a notable increase in cases in the United Kingdom. The effectiveness of the BNT162b2 and ChAdOx1 nCoV-19 vaccines against this variant has been unclear.MethodsWe used a test-negative case-control design to estimate the effectiveness of vaccination against symptomatic disease caused by the delta variant or the predominant strain (B.1.1.7, or alpha variant) over the period that the delta variant began circulating. Variants were identified with the use of sequencing and on the basis of the spike (S) gene status. Data on all symptomatic sequenced cases of Covid-19 in England were used to estimate the proportion of cases with either variant according to the patients' vaccination status.ResultsEffectiveness after one dose of vaccine (BNT162b2 or ChAdOx1 nCoV-19) was notably lower among persons with the delta variant (30.7%; 95% confidence interval [CI], 25.2 to 35.7) than among those with the alpha variant (48.7%; 95% CI, 45.5 to 51.7); the results were similar for both vaccines. With the BNT162b2 vaccine, the effectiveness of two doses was 93.7% (95% CI, 91.6 to 95.3) among persons with the alpha variant and 88.0% (95% CI, 85.3 to 90.1) among those with the delta variant. With the ChAdOx1 nCoV-19 vaccine, the effectiveness of two doses was 74.5% (95% CI, 68.4 to 79.4) among persons with the alpha variant and 67.0% (95% CI, 61.3 to 71.8) among those with the delta variant.ConclusionsOnly modest differences in vaccine effectiveness were noted with the delta variant as compared with the alpha variant after the receipt of two vaccine doses. Absolute differences in vaccine effectiveness were more marked after the receipt of the first dose. This finding would support efforts to maximize vaccine uptake with two doses among vulnerable populations. (Funded by Public Health England.).

Dataset Information

Genome Sequence of an Early Imported Case of SARS-CoV-2 Delta Variant (B.1.617.2 AY.122) in Iraq in April 2021.

Publications

Genome Sequence of an Early Imported Case of SARS-CoV-2 Delta Variant (B.1.617.2 AY.122) in Iraq in April 2021.

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