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Voltammetric determination of Molnupiravir used in treatment of the COVID-19 at magnetite nanoparticle modified carbon paste electrode.

ABSTRACT: To reduce the progression of the viral process in patients infected with COVID-19, new treatments and drug active substances are needed. One of these drugs is Molnupiravir (MNP) which has a direct antiviral effect and has also proven to be highly effective in reducing the azopharyngeal SARS-CoV-2 infectious virus and viral RNA. Due to the importance and frequent use of this drug in the treatment of COVID-19, its accurate, quick, and cheap detection in pharmaceutical or biological samples is crucial. In this work, electrochemical behavior and sensitive voltammetric determination of MNP are described using a magnetite nanoparticle modified carbon paste electrode (Fe₃O₄@CPE) for the first time. Fe₃O₄ nanoparticles (NPs) were characterized by recording their transmission electron microscopy (TEM) images, energy dispersive X-ray (EDX), and X-ray diffraction (XRD) spectra. Cyclic voltammetric measurements showed that MNP was irreversibly oxidized at Fe₃O₄@CPE at 760 mV in pH 2.0 Britton Robinson buffer solution (BRBS). The peak current of MNP was increased approximately threefold at Fe₃O₄@CPE compared to bare CPE due to a good electrocatalytic efficiency of Fe₃O₄ NPs. According to differential pulse voltammetric studies, the fabricated electrode exhibited a linear range (LR) between 0.25 and 750 µM with sensitivity and limit of detection (LOD) of 4591.0 µA mM^-1 cm^-2 and 0.05 µM, respectively. On the other hand, although lower sensitivity (327.3 µA mM^-1 cm^-2) was obtained from CV compared to DPV, a wider linear calibration curve between 0.25 and 1500 µM was obtained in CV. Studies performed in tablet samples confirmed that the Fe₃O₄@CPE exhibits high applicability for selective and accurate voltammetric determination of MNP in real samples.

SUBMITTER: Vural K

PROVIDER: S-EPMC9671532 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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Voltammetric determination of Molnupiravir used in treatment of the COVID-19 at magnetite nanoparticle modified carbon paste electrode.

Vural Kader K Karakaya Serkan S Dilgin Didem Giray DG Gökçel Hatice İsmet Hİ Dilgin Yusuf Y

Microchemical journal : devoted to the application of microtechniques in all branches of science 20221117

To reduce the progression of the viral process in patients infected with COVID-19, new treatments and drug active substances are needed. One of these drugs is Molnupiravir (MNP) which has a direct antiviral effect and has also proven to be highly effective in reducing the azopharyngeal SARS-CoV-2 infectious virus and viral RNA. Due to the importance and frequent use of this drug in the treatment of COVID-19, its accurate, quick, and cheap detection in pharmaceutical or biological samples is cruc ...[more]

PMID: 36415585

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Project description:Selenite (Se4+), a significant source of water pollution above the permissible limits, is considered a valuable metal by environmentalists. In this study, we described a novel electrochemical sensor that utilized a carbon paste electrode (CPE) that was modified using multiwall carbon nanotubes (MWCNTs) and poly(1-aminoanthraquinone) (p-AAQ) for finding Se4+ in water samples. Electrochemical quantification of Se4+ depends on the formation of a selective complex (piaselenol) with p-AAQ. In this work, we prepared a CPE modified by physical embedding of MWCNTs and 1-aminoanthraquione (AAQ), while the polymer film was formed by anodic polymerization of AAQ by applying a constant potential of 0.75 V in 0.1 M HCl for 20 s followed by cyclic voltammetry (CV) from -0.2 to 1.4 V for 20 cycles. The modified CPE was used for differential pulse voltammetry (DPV) of Se4+ in 0.1 M H2SO4 from 0 to 0.4 V with a characteristic peak at 0.27 V. Further, the proposed sensor was characterized by scanning electron microscopy, energy-dispersive X-ray spectroscopy, and electrochemical impedance spectroscopy (EIS). The analytical conditions regarding the electrode performance and voltammetric measurements were optimized, with the accumulation time and potential, supporting electrolyte, differential-pulse period/time, and amplitude. The EIS results indicated that the p-AAQ/MWCNTs-modified CPE sensor (p-AAQ/MWCNTs/CPE) that also exhibited low charge-transfer resistance (R ct) toward the anodic stripping of Se4+, exhibited good analytical performance toward different concentrations of Se4+ in a linear range of 5-50 μg L-1 Se4+ with a limit of determination (LOD) of 1.5 μg L-1 (3σ). Furthermore, differential-pulse voltammetry was employed to determine different concentrations of Se4+ in a linear range of 1-50 μg L-1 Se4+, and an LOD value of 0.289 μg L-1 was obtained. The proposed sensor demonstrated good precision (relative standard deviation = 4.02%) at a Se4+ concentration of 5 μg L-1. Moreover, the proposed sensor was applied to analyze Se4+ in wastewater samples that were spiked with Se, and it achieved good recovery values.

Dataset Information

Voltammetric determination of Molnupiravir used in treatment of the COVID-19 at magnetite nanoparticle modified carbon paste electrode.

Publications

Voltammetric determination of Molnupiravir used in treatment of the COVID-19 at magnetite nanoparticle modified carbon paste electrode.

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