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Differential expression of caprine beta-defensins in digestive and respiratory tissues.


ABSTRACT: We identified two novel beta-defensin precursors, preproGBD-1 and preproGBD-2, in the tissues of a goat. Although the precursors were identical in 96.8% of their bases and 88.2% (60 of 68) of their amino acids, preproGBD-1 was expressed principally in the tongue and respiratory tract, whereas preproGBD-2 expression predominated throughout the intestine. These findings exemplify the phenomenon of tissue-specific expression in a family of host defense peptides that arose before the avian and mammalian lineages diverged.

SUBMITTER: Zhao C 

PROVIDER: S-EPMC97022 | biostudies-literature | 1999 Nov

REPOSITORIES: biostudies-literature

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Differential expression of caprine beta-defensins in digestive and respiratory tissues.

Zhao C C   Nguyen T T   Liu L L   Shamova O O   Brogden K K   Lehrer R I RI  

Infection and immunity 19991101 11


We identified two novel beta-defensin precursors, preproGBD-1 and preproGBD-2, in the tissues of a goat. Although the precursors were identical in 96.8% of their bases and 88.2% (60 of 68) of their amino acids, preproGBD-1 was expressed principally in the tongue and respiratory tract, whereas preproGBD-2 expression predominated throughout the intestine. These findings exemplify the phenomenon of tissue-specific expression in a family of host defense peptides that arose before the avian and mamma  ...[more]

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