Differential expression of caprine beta-defensins in digestive and respiratory tissues.
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ABSTRACT:
SUBMITTER: Zhao C
PROVIDER: S-EPMC97022 | biostudies-literature | 1999 Nov
REPOSITORIES: biostudies-literature
Publications
Differential expression of caprine beta-defensins in digestive and respiratory tissues.
Zhao C C Nguyen T T Liu L L Shamova O O Brogden K K Lehrer R I RI
Infection and immunity 19991101 11
We identified two novel beta-defensin precursors, preproGBD-1 and preproGBD-2, in the tissues of a goat. Although the precursors were identical in 96.8% of their bases and 88.2% (60 of 68) of their amino acids, preproGBD-1 was expressed principally in the tongue and respiratory tract, whereas preproGBD-2 expression predominated throughout the intestine. These findings exemplify the phenomenon of tissue-specific expression in a family of host defense peptides that arose before the avian and mamma ...[more]
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