Ontology highlight
ABSTRACT:
SUBMITTER: Kneppers J
PROVIDER: S-EPMC9712620 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Kneppers Jeroen J Severson Tesa M TM Siefert Joseph C JC Schol Pieter P Joosten Stacey E P SEP Yu Ivan Pak Lok IPL Huang Chia-Chi Flora CF Morova Tunç T Altıntaş Umut Berkay UB Giambartolomei Claudia C Seo Ji-Heui JH Baca Sylvan C SC Carneiro Isa I Emberly Eldon E Pasaniuc Bogdan B Jerónimo Carmen C Henrique Rui R Freedman Matthew L ML Wessels Lodewyk F A LFA Lack Nathan A NA Bergman Andries M AM Zwart Wilbert W
Nature communications 20221130 1
Androgen receptor (AR) drives prostate cancer (PCa) development and progression. AR chromatin binding profiles are highly plastic and form recurrent programmatic changes that differentiate disease stages, subtypes and patient outcomes. While prior studies focused on concordance between patient subgroups, inter-tumor heterogeneity of AR enhancer selectivity remains unexplored. Here we report high levels of AR chromatin binding heterogeneity in human primary prostate tumors, that overlap with hete ...[more]