Ontology highlight
ABSTRACT:
SUBMITTER: Cheung MD
PROVIDER: S-EPMC9714795 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Cheung Matthew D MD Erman Elise N EN Moore Kyle H KH Lever Jeremie Mp JM Li Zhang Z LaFontaine Jennifer R JR Ghajar-Rahimi Gelare G Liu Shanrun S Yang Zhengqin Z Karim Rafay R Yoder Bradley K BK Agarwal Anupam A George James F JF
JCI insight 20221024 20
The kidney contains a population of resident macrophages from birth that expands as it grows and forms a contiguous network throughout the tissue. Kidney-resident macrophages (KRMs) are important in homeostasis and the response to acute kidney injury. While the kidney contains many microenvironments, it is unknown whether KRMs are a heterogeneous population differentiated by function and location. We combined single-cell RNA-Seq (scRNA-Seq), spatial transcriptomics, flow cytometry, and immunoflu ...[more]