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Copper-promoted direct sulfenylation of C1-H bonds in 4-aryl pyrrolo[1,2-a]quinoxalines.

ABSTRACT: Methods for direct functionalization of C(sp²)-H bonds in pyrrolo[1,2-a]quinoxalines have witnessed emerging development over the last decade. Herein we report a new tactic to afford a selective sulfenylation of 4-aryl pyrrolo[1,2-a]quinoxalines with diaryl disulfides. The reactions proceeded in the presence of a copper catalyst and potassium iodide promoter. Functionalities including nitro, ester, amide, methylthio, and halogen groups were all tolerated. Our method offers a convenient route to obtain highly substituted pyrrolo[1,2-a]quinoxalines-based thioethers in moderate to good yields.

SUBMITTER: Ca TT

PROVIDER: S-EPMC9727684 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Copper-promoted direct sulfenylation of C1-H bonds in 4-aryl pyrrolo[1,2-a]quinoxalines.

Ca Thuy T TT Le Khanh T M KTM Phan Son N T SNT Nguyen Huy H HH Le Huy X HX Phan Nam T S NTS Nguyen Tung T TT

RSC advances 20221207 54

Methods for direct functionalization of C(sp2)-H bonds in pyrrolo[1,2-a]quinoxalines have witnessed emerging development over the last decade. Herein we report a new tactic to afford a selective sulfenylation of 4-aryl pyrrolo[1,2-a]quinoxalines with diaryl disulfides. The reactions proceeded in the presence of a copper catalyst and potassium iodide promoter. Functionalities including nitro, ester, amide, methylthio, and halogen groups were all tolerated. Our method offe ...[more]

PMID: 36540248

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