Dataset Information

Long-term exposure to fine particulate matter modifies the association between physical activity and hypertension incidence.

ABSTRACT:

Background

The trade-off between the benefits of regular physical activity (PA) and the potentially detrimental effects of augmented exposure to air pollution in highly polluted regions remains unclear. This study aimed to examine whether ambient fine particulate matter (PM_2.5) exposure modified the impacts of PA volume and intensity on hypertension risk.

Methods

We included 54,797 participants without hypertension at baseline in a nationwide cohort of the Prediction for Atherosclerotic Cardiovascular Disease Risk in China (China-PAR) project. PA volume and intensity were assessed by questionnaire, and high-resolution (1 km ×1 km) PM_2.5 estimates were generated using a satellite-based model.

Results

During 413,516 person-years of follow-up, 12,100 incident hypertension cases were identified. PM_2.5 significantly modified the relationship between PA and hypertension incidence (p_interaction < 0.001). Increased PA volume was negatively associated with incident hypertension in the low PM_2.5 stratum (<59.8 μg/m³, p_trend < 0.001), with a hazard ratio of 0.81 (95% confidence interval (95%CI): 0.74-0.88) when comparing the fourth with the first quartile of PA volume. However, the health benefits were not observed in the high PM_2.5 stratum (≥59.8 μg/m³, p_trend = 0.370). Moreover, compared with light PA intensity, vigorous intensity was related to a 20% (95%CI: 9%-29%) decreased risk of hypertension for participants exposed to low PM_2.5, but a 17% (95%CI: 4%-33%) increased risk for those with high PM_2.5 levels.

Conclusion

PA was associated with a reduced risk of hypertension only among participants with low PM_2.5 exposure. Our findings recommended regular PA to prevent hypertension in less polluted regions and reinforced the importance of air quality improvement.

SUBMITTER: Liu Q

PROVIDER: S-EPMC9729921 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Publications

Long-term exposure to fine particulate matter modifies the association between physical activity and hypertension incidence.

Liu Qiong Q Huang Keyong K Liang Fengchao F Yang Xueli X Li Jianxin J Chen Jichun J Liu Xiaoqing X Cao Jie J Shen Chong C Yu Ling L Zhao Yingxin Y Deng Ying Y Li Ying Y Hu Dongsheng D Lu Xiangfeng X Liu Yang Y Gu Dongfeng D Liu Fangchao F Huang Jianfeng J

Journal of sport and health science 20220119 6

<h4>Background</h4>The trade-off between the benefits of regular physical activity (PA) and the potentially detrimental effects of augmented exposure to air pollution in highly polluted regions remains unclear. This study aimed to examine whether ambient fine particulate matter (PM<sub>2.5</sub>) exposure modified the impacts of PA volume and intensity on hypertension risk.<h4>Methods</h4>We included 54,797 participants without hypertension at baseline in a nationwide cohort of the Prediction fo ...[more]

PMID: 35065296

Similar Datasets

Project description:BACKGROUND:Long-term exposure to particulate matter (PM) air pollution may increase blood pressure and the risk of hypertension. However, epidemiological evidence is scarce and inconsistent. OBJECTIVES:We investigated the associations between long-term exposure to PM with an aerodynamic diameter <2.5?m (PM2.5), blood pressure, and incident hypertension in a large Taiwanese cohort. METHODS:We studied 361,560 adults ?18y old from a large cohort who participated in a standard medical examination program during 2001 to 2014. Among this group, 125,913 nonhypertensive participants were followed up. A satellite-based spatiotemporal model was used to estimate the 2-y average PM2.5 concentrations at each participant's address. Multivariable linear regression was used in the cross-sectional data analysis with the 361,560 participants to investigate the associations between PM2.5 and systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse pressure (PP), and Cox proportional hazard regression was used in the cohort data analysis with the 125,913 participants to investigate the associations between PM2.5 and incident hypertension. RESULTS:Each 10-?g/m3 increment in the 2-y average PM2.5 concentration was associated with increases of 0.45?mmHg [95% confidence interval (CI): 0.40, 0.50], 0.07?mmHg (95% CI: 0.04, 0.11), and 0.38?mmHg (95% CI: 0.33, 0.42) in SBP, DBP, and PP, respectively, after adjusting for a wide range of covariates and possible confounders. Each 10-?g/m3 increment in the 2-y average PM2.5 concentration was associated with an increase of 3% in the risk of developing hypertension [hazard?ratio=1.03 (95% CI: 1.01, 1.05)]. Stratified and sensitivity analyses yielded similar results. CONCLUSIONS:Long-term exposure to PM2.5 air pollution is associated with higher blood pressure and an increased risk of hypertension. These findings reinforce the importance of air pollution mitigation strategies to reduce the risk of cardiovascular disease. https://doi.org/10.1289/EHP2466.

Dataset Information

Long-term exposure to fine particulate matter modifies the association between physical activity and hypertension incidence.

Background

Methods

Results

Conclusion

Publications

Long-term exposure to fine particulate matter modifies the association between physical activity and hypertension incidence.

Similar Datasets

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