Purified exosome product enhances chondrocyte survival and regeneration by modulating inflammation and promoting chondrogenesis.
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ABSTRACT:
SUBMITTER: Shi G
PROVIDER: S-EPMC9732920 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Publications
Purified exosome product enhances chondrocyte survival and regeneration by modulating inflammation and promoting chondrogenesis.
Shi Guidong G Long Zeling Z De la Vega Rodolfo E RE Behfar Atta A Moran Steven L SL Evans Christopher C Zhao Chunfeng C
Regenerative medicine 20221018 1
<b>Aim:</b> This study was to detect the effects of purified exosome product (PEP) on C28/I2 cells and chondrocytes derived from osteoarthritis patients. <b>Materials & methods:</b> Cell viability and apoptosis assays were used to detect the effect of PEP on cells. qRT-PCR and cell fluorescence assays were used to investigate the potential mechanism of PEP on cell chondrogenesis. <b>Results:</b> PEP was internalized by cells at a fast rate and enhanced cellular proliferation and migration while ...[more]
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