Ontology highlight
ABSTRACT:
SUBMITTER: Oyston PC
PROVIDER: S-EPMC97616 | biostudies-literature | 2000 Jun
REPOSITORIES: biostudies-literature
Oyston P C PC Dorrell N N Williams K K Li S R SR Green M M Titball R W RW Wren B W BW
Infection and immunity 20000601 6
The two-component regulatory system PhoPQ has been identified in many bacterial species. However, the role of PhoPQ in regulating virulence gene expression in pathogenic bacteria has been characterized only in Salmonella species. We have identified, cloned, and sequenced PhoP orthologues from Yersinia pestis, Yersinia pseudotuberculosis, and Yersinia enterocolitica. To investigate the role of PhoP in the pathogenicity of Y. pestis, an isogenic phoP mutant was constructed by using a reverse-genet ...[more]