Ontology highlight
ABSTRACT:
SUBMITTER: van Doremalen N
PROVIDER: S-EPMC9768398 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
van Doremalen Neeltje N Avanzato Victoria A VA Goldin Kerry K Feldmann Friederike F Schulz Jonathan E JE Haddock Elaine E Okumura Atsushi A Lovaglio Jamie J Hanley Patrick W PW Cordova Kathleen K Saturday Greg G de Wit Emmie E Lambe Teresa T Gilbert Sarah C SC Munster Vincent J VJ
NPJ vaccines 20221221 1
Nipah virus (NiV) is a highly pathogenic and re-emerging virus, which causes sporadic but severe infections in humans. Currently, no vaccines against NiV have been approved. We previously showed that ChAdOx1 NiV provides full protection against a lethal challenge with NiV Bangladesh (NiV-B) in hamsters. Here, we investigated the efficacy of ChAdOx1 NiV in the lethal African green monkey (AGM) NiV challenge model. AGMs were vaccinated either 4 weeks before challenge (prime vaccination), or 8 and ...[more]