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Ni-catalyzed benzylic β-C(sp3)-H bond activation of formamides.

ABSTRACT: The development of transition metal-catalyzed β-C-H bond activation via highly-strained 4-membered metallacycles has been a formidable task. So far, only scarce examples have been reported to undergo β-C-H bond activation via 4-membered metallacycles, and all of them rely on precious metals. In contrast, earth-abundant and inexpensive 3d transition metal-catalyzed β-C-H bond activation via 4-membered metallacycles still remains an elusive challenge. Herein, we report a phosphine oxide-ligated Ni-Al bimetallic catalyst to activate secondary benzylic C(sp3)-H bonds of formamides via 4-membered nickelacycles, providing a series of α,β-unsaturated γ-lactams in up to 97% yield.

SUBMITTER: Wang RH

PROVIDER: S-EPMC9780214 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Ni-catalyzed benzylic β-C(sp<sup>3</sup>)-H bond activation of formamides.

Wang Rong-Hua RH Xu Wei-Wei WW Wu Hongli H Li Yue Y Li Jiang-Fei JF Zhang Tao T Huang Genping G Ye Mengchun M

Nature communications 20221222 1

The development of transition metal-catalyzed β-C-H bond activation via highly-strained 4-membered metallacycles has been a formidable task. So far, only scarce examples have been reported to undergo β-C-H bond activation via 4-membered metallacycles, and all of them rely on precious metals. In contrast, earth-abundant and inexpensive 3d transition metal-catalyzed β-C-H bond activation via 4-membered metallacycles still remains an elusive challenge. Herein, we report a phosphine oxide-ligated Ni ...[more]

PMID: 36550165

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