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Tunable Self-Assembled Peptide Hydrogel Sensor for Pharma Cold Supply Chain.

ABSTRACT: Defrost sensors are a crucial element for proper functioning of the pharmaceutical cold chain. In this paper, the self-assembled peptide-based hydrogels were used to construct a sensitive defrost sensor for the transportation and storage of medications and biomaterials. The turbidity of the peptide hydrogel was employed as a marker of the temperature regime. The gelation kinetics under different conditions was studied to detect various stages of hydrogel structural transitions aimed at tuning the system properties. The developed sensor can be stored at room temperature for a long period, irreversibly indicates whether the product has been thawed, and can be adjusted to a specific temperature range and detection time.

SUBMITTER: Tikhonova TN

PROVIDER: S-EPMC9782340 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Tunable Self-Assembled Peptide Hydrogel Sensor for Pharma Cold Supply Chain.

Tikhonova Tatiana N TN Cohen-Gerassi Dana D Arnon Zohar A ZA Efremov Yuri Y Timashev Peter P Adler-Abramovich Lihi L Shirshin Evgeny A EA

ACS applied materials & interfaces 20221208 50

Defrost sensors are a crucial element for proper functioning of the pharmaceutical cold chain. In this paper, the self-assembled peptide-based hydrogels were used to construct a sensitive defrost sensor for the transportation and storage of medications and biomaterials. The turbidity of the peptide hydrogel was employed as a marker of the temperature regime. The gelation kinetics under different conditions was studied to detect various stages of hydrogel structural transitions aimed at tuning th ...[more]

PMID: 36475602

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