Pediatric low-grade glioma: Targeted therapeutics and clinical trials in the molecular era.
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ABSTRACT:
SUBMITTER: Manoharan N
PROVIDER: S-EPMC9803951 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Publications
Pediatric low-grade glioma: Targeted therapeutics and clinical trials in the molecular era.
Manoharan Neevika N Liu Kevin X KX Mueller Sabine S Haas-Kogan Daphne A DA Bandopadhayay Pratiti P
Neoplasia (New York, N.Y.) 20221224
pLGGs are a group of tumors for which the era of molecular diagnostics has truly shifted treatment paradigms and patient care. The discovery that this group of tumors is driven by single-gene alterations/fusions in the MAPK pathway has resulted in relatively rapid translation into targeted therapy options for patients with this often chronic disease. This translation has been facilitated through efforts of multiple collaboratives and consortia and has led to the development of clinical trials te ...[more]
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