Ontology highlight
ABSTRACT:
SUBMITTER: Wizemann TM
PROVIDER: S-EPMC98061 | biostudies-literature | 2001 Mar
REPOSITORIES: biostudies-literature
Infection and immunity 20010301 3
Microbial targets for protective humoral immunity are typically surface-localized proteins and contain common sequence motifs related to their secretion or surface binding. Exploiting the whole genome sequence of the human bacterial pathogen Streptococcus pneumoniae, we identified 130 open reading frames encoding proteins with secretion motifs or similarity to predicted virulence factors. Mice were immunized with 108 of these proteins, and 6 conferred protection against disseminated S. pneumonia ...[more]