Circumvention of herd immunity during an outbreak of meningococcal disease could be correlated to escape mutation in the porA gene of Neisseria meningitidis.
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ABSTRACT:
SUBMITTER: Taha MK
PROVIDER: S-EPMC98115 | biostudies-literature | 2001 Mar
REPOSITORIES: biostudies-literature
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Circumvention of herd immunity during an outbreak of meningococcal disease could be correlated to escape mutation in the porA gene of Neisseria meningitidis.
Taha M K MK Bichier E E Perrocheau A A Alonso J M JM
Infection and immunity 20010301 3
Meningococcal strains isolated during an outbreak were shown to belong to the ET-5 complex and to harbor a mutation in the VR2 region of the porA gene. They were less susceptible to the bactericidal effect of normal human serum than was the ET-5 wild-type strain. These results are of concern, as PorA is a potential target in vaccine design. ...[more]
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