Dataset Information

Extracardiac findings with increased perfusion during clinical O-15-H₂O PET/CT myocardial perfusion imaging: A case series.

ABSTRACT:

Background

Coincidental extracardiac findings with increased perfusion were reported during myocardial perfusion imaging (MPI) with various retention radiotracers. Clinical parametric O-15-H₂O PET MPI yielding quantitative measures of myocardial blood flow (MBF) was recently implemented at our facility. We aim to explore whether similar extracardiac findings are observed using O-15-H₂O.

Methods and results

All patients (2963) were scanned with O-15-H₂O PET MPI according to international guidelines and extracardiac findings were collected. In contrast to parametric O-15-H₂O MBF images, extracardiac perfusion was assessed using summed images. Biopsy histopathology and other imaging modalities served as reference standards. Various malignant lesions with increased perfusion were detected, including lymphomas, large-celled neuroendocrine tumour, breast, and lung cancer plus metastases from colonic and renal cell carcinomas. Furthermore, inflammatory and hyperplastic benign conditions with increased perfusion were observed: rib fractures, gynecomastia, atelectasis, sarcoidosis, pneumonia, chronic lung inflammation and fibrosis, benign lung nodule, chronic diffuse lung infiltrates, pleural plaques and COVID-19 infiltrates.

Conclusions

Malignant and benign extracardiac coincidental findings with increased perfusion are readily visible and frequently seen on O-15-H₂O PET MPI. We recommend evaluating the summed O-15-H₂O PET images in addition to the low-dose CT attenuation images.

SUBMITTER: Jochumsen MR

PROVIDER: S-EPMC9812748 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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Publications

Extracardiac findings with increased perfusion during clinical O-15-H<sub>2</sub>O PET/CT myocardial perfusion imaging: A case series.

Jochumsen Mads Ryø MR Overgaard David Lyse DL Vendelbo Mikkel Holm MH Madsen Michael Alle MA Tolbod Lars Poulsen LP Gormsen Lars Christian LC Barkholt Trine Ørhøj TØ

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 20230105 4

<h4>Background</h4>Coincidental extracardiac findings with increased perfusion were reported during myocardial perfusion imaging (MPI) with various retention radiotracers. Clinical parametric O-15-H<sub>2</sub>O PET MPI yielding quantitative measures of myocardial blood flow (MBF) was recently implemented at our facility. We aim to explore whether similar extracardiac findings are observed using O-15-H<sub>2</sub>O.<h4>Methods and results</h4>All patients (2963) were scanned with O-15-H<sub>2</s ...[more]

PMID: 36600173

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Project description:BackgroundSeveral factors may decrease the accuracy of quantitative PET myocardial perfusion imaging (MPI). It is therefore essential to ensure that myocardial blood flow (MBF) values are reproducible and accurate, and to design systematic protocols to achieve this. Until now, no systematic phantom protocols have been available to assess the technical factors affecting measurement accuracy and reproducibility in MPI.Materials and methodsWe implemented a standard measurement protocol, which applies a flow phantom in order to compare image-derived flow values with respect to a ground truth flow value with [15O]H2O MPI performed on both a Discovery MI (DMI-20, GE Healthcare) and a Biograph Vision 600 (Vision-600, Siemens Healthineers) system. Both systems have automatic [15O]H2O radio water generators (Hidex Oy) individually installed, allowing us to also study the differences occurring due to two different bolus delivery systems. To investigate the technical factors contributing to the modelled flow values, we extracted the [15O]H2O bolus profiles, the flow values from the kinetic modeling (Qin and Qout), and finally calculated their differences between test-retest measurements on both systems.ResultsThe measurements performed on the DMI-20 system produced Qin and Qout values corresponging to each other as well as to the reference flow value across all test-retest measurements. The repeatability differences on DMI-20 were 2.1% ± 2.6% and 3.3% ± 4.1% for Qin and Qout, respectively. On Vision-600 they were 10% ± 8.4% and 11% ± 10% for Qin and Qout, respectively. The measurements performed on the Vision-600 system showed more variation between Qin and Qout values across test-retest measurements and exceeded 15% difference in 7/24 of the measurements.ConclusionsA preliminary protocol for measuring the accuracy and reproducibility of flow values in [15O]H2O MPI between digital PET/CT systems was assessed. The test-retest reproducibility falls below 15% in majority of the measurements conducted between two individual injector systems and two digital PET/CT systems. This study highlights the importance of implementing a standardized bolus injection and delivery protocol and importance of assessing technical factors affecting flow value reproducibility, which should be carefully investigated in a multi-center setting.

Dataset Information

Extracardiac findings with increased perfusion during clinical O-15-H₂O PET/CT myocardial perfusion imaging: A case series.

Background

Methods and results

Conclusions

Publications

Extracardiac findings with increased perfusion during clinical O-15-H<sub>2</sub>O PET/CT myocardial perfusion imaging: A case series.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Extracardiac findings with increased perfusion during clinical O-15-H2O PET/CT myocardial perfusion imaging: A case series.

Background

Methods and results

Conclusions

Publications

Extracardiac findings with increased perfusion during clinical O-15-H<sub>2</sub>O PET/CT myocardial perfusion imaging: A case series.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Extracardiac findings with increased perfusion during clinical O-15-H₂O PET/CT myocardial perfusion imaging: A case series.