Ontology highlight
ABSTRACT:
SUBMITTER: Wang H
PROVIDER: S-EPMC9814776 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Wang Hongzhi H Wu Jinming J Sternke-Hoffmann Rebecca R Zheng Wenwei W Mörman Cecilia C Luo Jinghui J
Communications chemistry 20221213 1
Amyloid-β (Aβ) peptide aggregation plays a central role in the progress of Alzheimer's disease (AD), of which Aβ-deposited extracellular amyloid plaques are a major hallmark. The brain micro-environmental variation in AD patients, like local acidification, increased ionic strength, or changed metal ion levels, cooperatively modulates the aggregation of the Aβ peptides. Here, we investigate the multivariate effects of varied pH, ionic strength and Zn<sup>2+</sup> on Aβ<sub>40</sub> fibrillation k ...[more]