Dataset Information

Effects of Kadsura coccinea L. Fruit Extract on Growth Performance, Meat Quality, Immunity, Antioxidant, Intestinal Morphology and Flora of White-Feathered Broilers.

ABSTRACT: This study aimed to determine whether adding Kadsura coccinea fruit extract to the diet of broilers could replace antibiotics. For this study, 300 one-day-old AA white feathered broilers were divided into five groups (no sex separated), with six repetitions per group (n = 10), as follows: blank control group (basal feed, CK group), positive drug (basal feed + 300 mg/kg aureomycin, PD group), and Kadsura coccinea low-dose, medium-dose, and high-dose groups (basal feed + 100 mg/kg, 200 mg/kg, and 300 mg/kg of Kadsura coccinea fruit extract, LD group, MD group and HD group). The experiment period was divided into early (1−21 days) and late (22−42 days) stage. We found that supplementation with Kadsura coccinea fruit extract in the diet significantly improved the growth performance of broilers (p < 0.05), reduced the feed to meat ratio (p < 0.05), reduced the fat percentage (p < 0.05), while had no significant effect on meat quality (p > 0.05) and Kadsura coccinea fruit extract could promote the development of immune organs to different extents, enhance antioxidant capacity, the contents of SOD and GSH-Px in serum were significantly increased (p < 0.05), improve the ratio of villus height to crypt depth. Finally, Kadsura coccinea fruit extract increased the relative abundance of probiotics and beneficial bacteria (Bacteroidales, NK4A214, Subdoligranulum and Eubacterium hallii) (p < 0.05) and reduced the relative abundance of harmful bacteria (Erysipelatoclostridium) (p < 0.05) in the gut of broilers. Compared with positive drug group, most of the indexes in the medium-dose group were better or had similar effects. We believe that Kadsura coccinea fruit extract can be used as a potential natural antibiotic substitute in livestock and poultry breeding programs.

SUBMITTER: Zhang T

PROVIDER: S-EPMC9817888 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Effects of <i>Kadsura coccinea</i> L. Fruit Extract on Growth Performance, Meat Quality, Immunity, Antioxidant, Intestinal Morphology and Flora of White-Feathered Broilers.

Zhang Tianlu T Zhou Dong D Wang Xin X Xiao Tian T Wu Lingxi L Tang Qi Q Lu Ying Y

Animals : an open access journal from MDPI 20221226 1

This study aimed to determine whether adding Kadsura coccinea fruit extract to the diet of broilers could replace antibiotics. For this study, 300 one-day-old AA white feathered broilers were divided into five groups (no sex separated), with six repetitions per group (n = 10), as follows: blank control group (basal feed, CK group), positive drug (basal feed + 300 mg/kg aureomycin, PD group), and Kadsura coccinea low-dose, medium-dose, and high-dose groups (basal feed + 100 mg/kg, 200 mg/kg, and ...[more]

PMID: 36611702

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Project description:Kadsura spp. in the Schisandraceae family are woody vine plants, which produce edible red fruits that are rich in nutrients and antioxidant activities. Despite their valuable food applications, Kadsura spp. are only able to grow naturally in the forest, and reproduction handled by botanists is still in progress with a very low growth rate. Subsequently, Kadsura spp. were listed as endangered species by the International Union for Conservation of Nature and Natural Resources (IUCN) in 2011. Two different Kadsura spp., including Kadsura coccinea (Lem.) A.C. Sm. and Kadsura heteroclita (Roxb.) Craib, are mostly found in northern Thailand. These rare, wild fruits are unrecognizable to outsiders, and there have only been limited investigations into its biological properties. This study, therefore, aimed to comparatively investigate the phenolic profiles, antioxidant activities, and inhibitory activities against the key enzymes involved in diabetes (α-glucosidase and α-amylase) and Alzheimer's disease (acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and beta-secretase 1 (BACE-1)) in different fruit parts (exocarp, mesocarp (edible part), seed, and core) of Kadsura coccinea (Lem.) A.C. Sm. and Kadsura heteroclita (Roxb.) Craib. The results suggested that Kadsura spp. extracts were rich in flavonol (quercetin), flavanone (naringenin), anthocyanidins (cyanidin and delphinidin), and anthocyanins (cyanidin 3-O-glucoside (kuromanin), cyanidin 3-O-galactoside (ideain), cyanidin 3-O-rutinoside (keracyanin), and cyanidin 3,5-di-O-glucoside (cyanin)). These flavonoids were found to be responsible for the high antioxidant activities and key enzyme inhibitions detected in Kadsura spp. extracts. The findings of the present study can support further development of Kadsura spp. as a potential source of phenolics and anti-oxidative agents with health benefits against diabetes and Alzheimer's disease. Besides, exocarp and the core of Kadsura spp. exhibited higher phenolic contents, antioxidant activities, and key enzyme inhibitory activities compared to the mesocarp and seeds, respectively. This information can promote the use of fruit parts other than the edible mesocarp for future food applications using Kadsura spp. rather than these being wasted.

Project description:This study was designed to evaluate the effects of different doses of the fibrous roots of Polygonatum cyrtonema Hua on the growth performance, slaughter parameters, meat quality, immune function, cytokines, antioxidant capacity, and intestinal morphology of white-feathered broilers. Also, the mechanism to improve immune functions of broilers was explored through network pharmacology and molecular docking technology. A total of 360 AA-white-feathered broilers were randomly divided into six groups (not separated by sex), with six repetitions per group (n = 10). The groups were as follows: basal diet (CON group), basal diet supplemented with 300 mg/kg aureomycin (ANT group), basal diet supplemented with 2%, 3%, and 4% fibrous root raw powder (LD, MD, and HD group), or basal diet supplemented with 3% fibrous root processed powder (PR group), in a 42-day experiment. The dietary inclusion of P. cyrtonema fibrous roots increased slaughter performance (p < 0.05), reduced the fat rate (p < 0.05), improved intestinal morphology (p < 0.05), and improved the immune organ index to varying degrees. It also significantly improved pH reduction, drip loss, and pressure loss of breast muscle and leg muscle (p < 0.05). Furthermore, it significantly improved immune and antioxidant functions including decreased MDA content of serum (p < 0.01), increased GSH-Px content (p < 0.01), IgG, IgA, and C4 contents (p < 0.05), and increased expression of IL-2 and IFN-γ (p < 0.01). Additionally, the mechanism by which fibrous roots improve immune function in broilers was explored using network pharmacology and molecular docking technology. Network pharmacology and molecular docking revealed that flavonoids such as baicalein, 4',5-Dihydroxyflavone, 5,7-dihydroxy-6,8-dimethyl-3-(4'-hydroxybenzyl)-chroman-4-one, and 5,7-dihydroxy-3-(2'-hydroxy-4'-methoxybenzyl)-6,8-dimethyl-chroman-4-one were key components that enhanced immune function through the MAPK1 and other key targets involved in regulating the MAPK signaling pathway. From the findings, it can be concluded that incorporating P. cyrtonema Hua fibrous root as a natural feed supplement and growth promoter in broiler diets had a positive impact on bird health and performance.

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Dataset Information

Effects of Kadsura coccinea L. Fruit Extract on Growth Performance, Meat Quality, Immunity, Antioxidant, Intestinal Morphology and Flora of White-Feathered Broilers.

Publications

Effects of <i>Kadsura coccinea</i> L. Fruit Extract on Growth Performance, Meat Quality, Immunity, Antioxidant, Intestinal Morphology and Flora of White-Feathered Broilers.

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