Fullerenols Prevent Neuron Death and Reduce Oxidative Stress in Drosophila Huntington's Disease Model.
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ABSTRACT:
SUBMITTER: Bolshakova OI
PROVIDER: S-EPMC9818496 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Publications
Fullerenols Prevent Neuron Death and Reduce Oxidative Stress in <i>Drosophila</i> Huntington's Disease Model.
Bolshakova Olga I OI Borisenkova Alina A AA Golomidov Ilya M IM Komissarov Artem E AE Slobodina Alexandra D AD Ryabova Elena V EV Ryabokon Irina S IS Latypova Evgenia M EM Slepneva Elizaveta E EE Sarantseva Svetlana V SV
Cells 20221231 1
Huntington's disease (HD) is one of the human neurodegenerative diseases for which there is no effective treatment. Therefore, there is a strong demand for a novel neuroprotective agent that can alleviate its course. Fullerene derivatives are considered to be such agents; however, they need to be comprehensively investigated in model organisms. In this work, neuroprotective activity of C<sub>60</sub>(OH)<sub>30</sub> and C<sub>120</sub>O(OH)<sub>44</sub> fullerenols was analyzed for the first ti ...[more]
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