Ontology highlight
ABSTRACT:
SUBMITTER: Zheng Q
PROVIDER: S-EPMC5288309 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Zheng Qiuyang Q Zheng Xiaoyuan X Zhang Lishan L Luo Hong H Qian Lingzhi L Fu Xing X Liu Yiqian Y Gao Yuehong Y Niu Mengxi M Meng Jian J Zhang Muxian M Bu Guojun G Xu Huaxi H Zhang Yun-Wu YW
Molecular neurobiology 20160621 6
TMEM59L is a newly identified brain-specific membrane-anchored protein with unknown functions. Herein we found that both TMEM59L and its homolog, TMEM59, are localized in Golgi and endosomes. However, in contrast to a ubiquitous and relatively stable temporal expression of TMEM59, TMEM59L expression was limited in neurons and increased during development. We also found that both TMEM59L and TMEM59 interacted with ATG5 and ATG16L1, and that overexpression of them triggered cell autophagy. However ...[more]